(Bio)organic Synthesis
Organic synthesis of reference compounds is performed (i) to unequivocally confirm the chemical structure and stereochemistry of a previously not reported natural product, (ii) to perform bioactivity studies with suitable amounts of a target molecule, and (iii) to perform accurate quantitative analyses using stable isotope labeled twin molecules of the target analytes as internal standards.
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If suitable, target compounds are synthesized by using the metabolic power of microorganisms fed with suitable precursor molecules. For the first time, this biosynthetic approach successfully allowed the synthesis of a 13C-labelled twin molecule of cereulide, the emetic toxin of Bacillus cereus, and enabled the development of a stable isotope dilution analysis.
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